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1

Somatic gene therapy for human disease: a problem of eugenics?

Journal:

Trends in Genetics

Year:

1987

Language:

english

File:

PDF, 463 KB

english, 1987

2

Profitability of Large Pharmaceutical Companies Compared With Other Large Public Companies

Ledley, Fred D., McCoy, Sarah Shonka, Vaughan, Gregory, Cleary, Ekaterina Galkina

Journal:

Year:

2020

File:

PDF, 416 KB

2020

3

Profitability of Large Pharmaceutical Companies Compared With Other Large Public Companies

Ledley, Fred D., McCoy, Sarah Shonka, Vaughan, Gregory, Cleary, Ekaterina Galkina

Journal:

Obstetric and Gynecologic Survey

Year:

2020

File:

PDF, 74 KB

2020

4

Nonviral Gene Therapy: The Promise of Genes as Pharmaceutical Products

Ledley, Fred D.

Journal:

Human Gene Therapy

Year:

1995

Language:

english

File:

PDF, 689 KB

english, 1995

5

Landscape of Innovation for Cardiovascular Pharmaceuticals: From Basic Science to New Molecular Entities

Beierlein, Jennifer M., McNamee, Laura M., Walsh, Michael J., Kaitin, Kenneth I., DiMasi, Joseph A., Ledley, Fred D.

Journal:

Clinical Therapeutics

Year:

2017

Language:

english

File:

PDF, 25.10 MB

english, 2017

6

The subcutaneous spleen: A new model for hepatocellular transplantation

Mary L. Brandt, Jordan W. Eckert, Humberto Soriano, Carla Buerkle, Fred Ledley, William J. Pokomy

Journal:

Journal of Pediatric Surgery

Year:

1993

Language:

english

File:

PDF, 165 KB

english, 1993

7

Making the biotech IPO work

McNamee, Laura, Ledley, Fred

Journal:

Nature Biotechnology

Year:

2013

Language:

english

File:

PDF, 264 KB

english, 2013

8

Evolution and the Human Tail

Ledley, Fred D.

Journal:

Boston Medical and Surgical Journal

Year:

1982

Language:

english

File:

PDF, 1.38 MB

english, 1982

9

Methods Used to Assess Pharmaceutical Research and Development Costs

Ledley, Fred D.

Journal:

JAMA Internal Medicine

Year:

2018

Language:

english

File:

PDF, 91 KB

english, 2018

10

Mutations in mut methylmalonic acidemia: Clinical and enzymatic correlations

Fred D. Ledley, David S. Rosenblatt

Journal:

Year:

1997

Language:

english

File:

PDF, 128 KB

english, 1997

11

Varying neurological phenotypes among mut° and mut− patients with methylmalonylCoA mutase deficiency

Michael I. Shevell, Nora Matiaszuk, Fred D. Ledley, David S. Rosenblatt

Journal:

American Journal of Medical Genetics Part A

Year:

1993

Language:

english

File:

PDF, 574 KB

english, 1993

12

Perspectives on methylmalonic acidemia resulting from molecular cloning of methylmalonyl CoA mutase

Journal:

Year:

1990

Language:

english

File:

PDF, 758 KB

english, 1990

13

Directional coronary atherectomy can be successfully performed in the elderly

Herman D. Movsowitz, Athanassios Manginas, Ronald P. Emmi, Jeffrey Bruss, Sri Kothapali, Elizabeth Wells, Gary S. Ledley, Morris N. Kotler, Fred K. Nakhjavan, Shahriar Yazdanfar

Journal:

Catheterization and Cardiovascular Interventions

Year:

1994

Language:

english

File:

PDF, 276 KB

english, 1994

14

Hepatic gene therapy: Present and future

Journal:

Year:

1993

Language:

english

File:

PDF, 1.26 MB

english, 1993

15

Non-viral gene therapy

Journal:

Current Opinion in Biotechnology

Year:

1994

Language:

english

File:

PDF, 1.14 MB

english, 1994

16

Phenotype of disease in three patients with identical mutations in methylmalonyl CoA mutase

Ana Maria Crane, Laura S. Martin, David Valle, Fred D. Ledley

Journal:

Year:

1992

Language:

english

File:

PDF, 736 KB

english, 1992

17

Biochemical Defect of the hph-1 Mouse Mutant Is a Deficiency in GTP-Cyclohydrolase Activity

J. David McDonald, Richard G. H. Cotton, Ian Jennings, Fred D. Ledley, Savio L. C. Woo, Vernon C. Bode

Journal:

Journal of Neurochemistry

Year:

1988

Language:

english

File:

PDF, 276 KB

english, 1988

18

10.1038/11614

Ledley, Fred D.

Journal:

Nature Biotechnology

Year:

1999

Language:

english

File:

PDF, 43 KB

english, 1999

19

Why pharmacogenomics? Why now?

Housman, David, Ledley, Fred D.

Journal:

Nature Biotechnology

Year:

1998

Language:

english

File:

PDF, 178 KB

english, 1998

20

Why pharmacogenomics? Why now?

Housman, David, Ledley, Fred D.

Journal:

Nature Biotechnology

Year:

1998

File:

PDF, 326 KB

1998

21

A consumer charter for genomic services

Journal:

Nature Biotechnology

Year:

2002

Language:

english

File:

PDF, 46 KB

english, 2002

22

Pharmaceutical Approach to Somatic Gene Therapy

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 4.34 MB

1996

23

Correction of methylmalonyl-CoA mutase deficiency inMutofibroblasts and constitution of gene expression in primary human hepatocytes by retroviral-mediated gene transfer

Takako Sawada, Fred D. Ledley

Journal:

Somatic Cell and Molecular Genetics

Year:

1992

Language:

english

File:

PDF, 1015 KB

english, 1992

24

Propionate metabolism in cultured human cells after overexpression of recombinant methylmalonyl CoA mutase: Implications for somatic gene therapy

Michael Wilkemeyer, Jozsef Stankovics, Thomas Foy, Fred D. Ledley

Journal:

Somatic Cell and Molecular Genetics

Year:

1992

Language:

english

File:

PDF, 1.31 MB

english, 1992

25

Physical and genetic localization of quinonoid dihydropteridine reductase gene (QDPR) on short arm of chromosome 4

Marcy E. MacDonald, Mary Anne Anderson, Jean L. Lockyer, Sheldon Milstien, Wendy J. Hobbs, Anne G. Faryniarz, Seymour Kaufman, Fred D. Ledley, Savio L. C. Woo, James F. Gusella

Journal:

Somatic Cell and Molecular Genetics

Year:

1987

Language:

english

File:

PDF, 587 KB

english, 1987

26

Assignment of human tryptophan hydroxylase locus to chromosome 11: Gene duplication and translocation in evolution of aromatic amino acid hydroxylases

Fred D. Ledley, Hernan E. Grenett, David P. Bartos, Peter van Tuinen, David H. Ledbetter, Savio L. C. Woo

Journal:

Somatic Cell and Molecular Genetics

Year:

1987

Language:

english

File:

PDF, 478 KB

english, 1987

27

Selection for phenylalanine hydroxylase activity in cells transformed with recombinant retroviruses

Fred D. Ledley, Tina Hahn, Savio L. C. Woo

Journal:

Somatic Cell and Molecular Genetics

Year:

1987

Language:

english

File:

PDF, 960 KB

english, 1987

28

Molecular biology of phenylalanine hydroxylase and phenylketonuria

Fred D. Ledley, Anthony G. DiLella, Savio L.C. Woo

Journal:

Trends in Genetics

Year:

1985

Language:

english

File:

PDF, 517 KB

english, 1985

29

Pharmacokinetic considerations in somatic gene therapy

Fred D Ledley, Tamara Shapiro Ledley

Journal:

Advanced Drug Delivery Reviews

Year:

1998

Language:

english

File:

PDF, 319 KB

english, 1998

30

DNA-and viral-mediated gene transfer in follicular cells: Progress toward gene therapy of the thyroid

Bert W. O'Malley Jr., Fred D. Ledley

Journal:

The Laryngoscope

Year:

1993

File:

PDF, 1.12 MB

1993

31

Gene transfer into human thyroid follicular cells

Bert W. O'Malley Jr., R. Mark Adams, Michael L. Sikes, Fred D. Ledley

Journal:

The Laryngoscope

Year:

1994

File:

PDF, 904 KB

1994

32

P-Chlorophenylalanine does not inhibit production of recombinant human phenylalanine hydroxylase in NIH3T3 cells or E. coli

Fred D. Ledley, Savio L.C. Woo

Journal:

Biochemical and Biophysical Research Communications

Year:

1987

Language:

english

File:

PDF, 907 KB

english, 1987

33

Is there methylmalonyl CoA mutase in Aspergillus nidulans?

Fred D. Ledley, Ana Maria Crane, Kathryn T. Klish, Gregory S. May

Journal:

Biochemical and Biophysical Research Communications

Year:

1991

Language:

english

File:

PDF, 391 KB

english, 1991

34

Computer analysis of ultrasoundcardiograms

Fred D. Ledley, James B. Wilson

Journal:

Computers in Biology and Medicine

Year:

1974

Language:

english

File:

PDF, 8.67 MB

english, 1974

35

Ketoacidotic crisis as a presentation of mild (“benign”) methylmalonic acidemia

Stuart K. Shapira, Fred D. Ledley, David S. Rosenblatt, Harvey L. Levy

Journal:

The Journal of Pediatrics

Year:

1991

Language:

english

File:

PDF, 523 KB

english, 1991

36

Directional coronary atherectomy in women compared with men

Herman D. Movsowitz, Ronald P. Emmi, Athanassios Manginas, Elizabeth Wells, Gary S. Ledley, Morris N. Kotler, Fred K. Nakhjavan, Shahriar Yazdanfar

Journal:

Clinical Cardiology

Year:

1994

Language:

english

File:

PDF, 547 KB

english, 1994

37

Sequence similarity between cholera toxin and glycoprotein hormones: Implications for structure activity relationship and mechanism of action

Fred D. Ledley, Brian R. Mullin, George Lee, Salvatore M. Aloj, Peter H. Fishman, Lois T. Hunt, Margaret O. Dayhoff, Leonard D. Kohn

Journal:

Biochemical and Biophysical Research Communications

Year:

1976

Language:

english

File:

PDF, 487 KB

english, 1976

38

Separation of the glycoprotein and ganglioside components of thyrotropin receptor activity in plasma membranes

Maria F. Meldolesi, Peter H. Fishman, Salvatore M. Aloj, Fred D. Ledley, George Lee, Roy M. Bradley, Roscoe O. Brady, Leonard D. Kohn

Journal:

Biochemical and Biophysical Research Communications

Year:

1977

Language:

english

File:

PDF, 450 KB

english, 1977

39

Thyrotropin interactions with human fat cell membrane preparations and the finding of a soluble thyrotropin binding component

Brian R. Mullin, George Lee, Fred D. Ledley, Roger J. Winand, Leonard D. Kohn

Journal:

Biochemical and Biophysical Research Communications

Year:

1976

Language:

english

File:

PDF, 381 KB

english, 1976

40

Somatic gene therapy for human disease: Background and prospects. Part II

Journal:

The Journal of Pediatrics

Year:

1987

Language:

english

File:

PDF, 727 KB

english, 1987

41

Somatic gene therapy for human disease: Background and prospects. Part I

Journal:

The Journal of Pediatrics

Year:

1987

Language:

english

File:

PDF, 737 KB

english, 1987

42

Correlation between polymorphic DNA haplotypes at phenylalanine hydroxylase locus and clinical phenotypes of phenylketonuria

Flemming Güttler, Fred D. Ledley, Alan S. Lidsky, Anthony G. DiLella, Susan E. Sullivan, Savio L.C. Woo

Journal:

The Journal of Pediatrics

Year:

1987

Language:

english

File:

PDF, 363 KB

english, 1987

43

Phenylalanine hydroxylase expression in liver of a fetus with phenylketonuria

Fred D. Ledley, Richard Koch, Kathrine Jew, Arthur Beaudet, William E. O'Brien, David P. Bartos, Savio L.C. Woo

Journal:

The Journal of Pediatrics

Year:

1988

Language:

english

File:

PDF, 1.45 MB

english, 1988

44

Replies

Journal:

The Journal of Pediatrics

Year:

1989

Language:

english

File:

PDF, 224 KB

english, 1989

45

Designing Clinical Trials of Somatic Gene Therapy

Journal:

Annals of the New York Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 687 KB

english, 1994

46

Patterns of technological innovation in biotech

McNamee, Laura M, Ledley, Fred D

Journal:

Nature Biotechnology

Year:

2012

Language:

english

File:

PDF, 532 KB

english, 2012

47

Cloning of full-length methylmalonyl-CoA mutase from a cDNA library using the polymerase chain reaction

Jansen, Ruud, Kalousek, Frantisek, Fenton, Wayne A., Rosenberg, Leon E., Ledley, Fred D.

Journal:

Year:

1989

Language:

english

File:

PDF, 1014 KB

english, 1989

48

Synteny on mouse chromosome 5 of homologs for human DNA loci linked to the Huntington disease gene

Cheng, Shirley V., Martin, Gail R., Nadeau, Joseph H., Haines, Jonathan L., Bucan, Maja, Kozak, Christine A., MacDonald, Marcy E., Lockyer, Jean L., Ledley, Fred D., Woo, Savio L.C.

Journal:

Year:

1989

Language:

english

File:

PDF, 985 KB

english, 1989

49

Retroviral mediated transfer and expression of human alpha1-antitrypsin in cultured cells

Ledley, Fred D., Grenett, Hernan E., Bartos, David P., Woo, Savio L.C.

Journal:

Year:

1987

Language:

english

File:

PDF, 664 KB

english, 1987

50

Structure of the human methylmalonyl-CoA mutase (MUT) locus

Nham, Sang-Uk, Wilkemeyer, Michael F., Ledley, Fred D.

Journal:

Year:

1990

Language:

english

File:

PDF, 2.47 MB

english, 1990